Via Mississippi State University: MSU researcher finds link to H5N1 bird flu. Excerpt:
A Mississippi State University researcher has uncovered the first molecular evidence linking live poultry markets in China to human H5N1 avian influenza.
Henry Wan, an assistant professor in systems biology at MSU’s College of Veterinary Medicine, collaborated with scientists in the World Health Organization Collaborative Centers for Influenza in China and St. Jude Children’s Research Hospital to investigate the connection.
“Although conceptually we knew live bird markets posed a risk for human H5N1 infection, there had previously not been any direct evidence, especially molecular evidence, supporting this hypothesis,” Wan said.
Based on information provided by patients infected with the H5N1 virus during the 2008-2009 season, Wan and his colleagues collected and analyzed 69 environmental samples from the live bird markets visited by six patients before the onset of the disease.
“From these 69 samples, we isolated a total of 12 highly pathogenic H5N1 avian influenza viruses from four of the six live bird markets. The similarity of the genetic sequence of the environmental and corresponding human isolates demonstrates a solid link between human infection and live poultry markets,” Wan said.
Wan said the goal of his research is to find the sources of human H5N1 infections and provide the foundations for policy-making for protecting public health. While the United States has regulations in place to protect consumers, this is not the case in all countries.
Wan began studying avian influenza while conducting graduate work in southern China in 1996. He was the first scientist to identify the highly pathogenic H5N1 avian influenza virus. One year later, this virus infected humans in Hong Kong, resulting in six deaths.
The subsequent massive depopulation of poultry stopped the human outbreak for a time, but two cases identified in Hong Kong in 2003 confirmed the virus was still circulating in the region and posed a health hazard. From 2003 to 2011, the World Health Organization recorded a total of 566 confirmed human cases for avian influenza worldwide that have resulted in 332 deaths.
To date, there have not been any highly pathogenic H5N1 detections in the United States.
Wan, whose other area of expertise is developing computer programs to model the mutation of viruses and to identify vaccine strains, performed an evolutionary study on this virus to identify the links between the human and avian strains of the virus at the molecular level.
“H5N1 viruses have spread to both wild and domestic bird populations in many countries, predominately in Asia, Africa and Europe,” Wan said.
Although no sustained human-to-human transmissions of the H5N1 virus have been confirmed, the mortality rate among human cases to date is about 60 percent. Wan hopes the results of this study can be used to develop policies to prevent and control H5N1 infections in humans.
“For instance, control and regulations of live bird markets could be used to help prevent the H5N1 human infections in areas that have active live bird markets,” he said.