EU funding has supported a major initiative designed to promote research collaboration to support control programmes for Chagas disease in central and southern America.
Chagas disease is caused by a protozoan Trypanosoma cruzi and is contracted mainly in central and southern America. Spread primarily by blood-sucking insect vectors, most commonly species of the Triatoma and Rhodnius genera, the disease can produce life-threatening symptoms in around a third of chronically infected individuals.
One feature of the life-cycle of the insect vector is that deforestation encourages the search for new food sources, in this case human blood, and a human transmission cycle may develop. The 'American trypanosomiasis update' (ATU) project therefore focused on control activities against the triatomine bug vector.
ATU researchers aimed to investigate the evolutionary processes involved in adaptation from a sylvatic (forest) to a domestic environment and to set up workshops to disseminate the collated information. Three regional initiatives were set up in southern cone countries, the Andean Pact and central America.
In field studies, samples of insects were collected and analysed before comparing with data from before the start of the bug control campaign. The species under study depended on the region as, for example, in the southern cone countries. In this region, T. infestans has been eliminated so the study also focused on other vector species. In the Andean countries, both domestic and sylvatic species came under investigation.