Via the always interesting blog Infection Landscapes: Marburg Hemorrhagic Fever. Excerpt:
The Disease. Marburg hemorrhagic fever (MHF) is characterized by an abrupt onset presenting with myalgia, fever, and chills. Abdominal pain and/or nausea with diarrhea and/or vomiting are also common. There are two important features of MHF that are critical in its pathogenesis: 1) endothelial damage mediated by both the virus and the up-regulation of toxic cytokines, which leads to extensive vascular leakage, and 2) disseminated intravascular coagulation, which leads to severe thrombocytopenia. ...
Hemorrhage, often severe, thus ensues and can be seen at several sites within approximately 5 to 7 days of the onset of symptoms. Bleeding from the nose, gums, and eyes is common, and extensive gastrointestinal hemorrhage will often manifest as frank blood in the stool or hematemesis. Dehydration is very common.Significant lesions can be found in multiple organs including the kidneys, spleen, liver, and lymph nodes. Mortality is high, typically ranging from 50% to 90% depending on the species and strain of MARV.
