Via Emerging Infectious Diseases, an expedited letter: Avian Influenza A(H7N9) Virus Infection in Pregnant Woman, China, 2013. Excerpt:
In February 2013, human infection with reassortant avian influenza A(H7N9) virus occurred in eastern China. A total of 135 laboratory-confirmed cases and 44 deaths among case-patients have been reported as of August 11, 2013. Unlike infection with other H7 subtype viruses (e.g., H7N2, H7N2, and H7N7), which often cause mild-to-moderate-human disease (1), infection with H7N9 subtype virus caused severe pneumonia and acute respiratory distress syndrome in most laboratory-confirmed case-patients (2,3).
Pregnant women are particularly susceptible to severe complications from influenza (seasonal and pandemic), and have an increased risk for maternal death (4).
On March 30, 2013, a 25-year-old pregnant woman came to the outpatient department of a hospital in Zhenjiang, Jiangsu Province, China. She had cough and fever (temperature 38.0°C), which had begun 2 days earlier. She also reported mild myalgia and mild sore throat. The patient had no any underlying medical conditions and was at 17 weeks gestation, as estimated by ultrasound. On April 5, she was admitted to the respiratory department of the hospital with a temperature of 39.9°C, a leukocyte count of 7.9 ×109 cells/L, and a lymphocyte count of 0.7 × 109 cells/L.
On April 6, she was transferred to the intensive care unit because of shortness of breath, respiratory failure, and loss of consciousness. She was given mechanical ventilation, broad-spectrum antimicrobial drugs, oseltamivir, gamma-globulin, antifibrotic therapy (glutathione), and nutritional support. Oseltamivir (150 mg/d, 2 times/d) had been administered during April 6–12. A chest radiograph showed extensive infiltrates of both lungs.
On April 21, she regained consciousness, and her condition stabilized over the next few days. On April 23, she was extubated, transferred to the common ward, and given nasal oxygen supplementation and antimicrobial and antifibrotic drug therapy. Her condition improved gradually, and on May 14 she was discharged in good health without fetal abnormality.
The fetus was monitored daily by using ultrasound to check the heart rate; fetal heart rate and activity were normal during hospitalization. The fetus continued to grow appropriately and was delivered by cesarean section at 35 weeks gestation on July 17 (length 48 cm, weight 3,300 g, and Apgars scores of 9 at 1 min and 10 at 5 min). The clinical timeline for the case-patient is shown in the Figure.
The patient and her husband lived in a house with her husband’s parents. No live poultry were present in the residential district, but the husband’s parents worked as pork butchers in a live animal market ≈500 m from the residential district. Several kinds of live poultry (e.g., chicken, duck, pigeon, and quail) were sold in the market. During the 2 weeks before illness onset, the patient did not have contact with persons known to be febrile. However, during that time, she visited the live animal market once.
Eighteen potential close contacts of the patient were identified (15 health care workers and 3 household members). Respiratory symptoms did not develop in any of these contacts during a 7-day surveillance period.