ECDC has published Summary of Public health threats, CDTR week 22/2016. Click or tap through for links.
The ECDC Communicable Disease Threats Report (CDTR) is a weekly bulletin for epidemiologists and health professionals about active public health threats. This issue covers the period 29 May to 4 June 2016 and includes updates on Enterovirus A71, colistin resistance mechanism MCR-1, and West Nile virus in Europe.
Enterovirus A71, Catalonia, Spain
An outbreak of enterovirus with neurological complications caused by enterovirus A71 has been ongoing in Catalonia since mid April 2016. As of 31 May, 73 cases of enterovirus infection with neurological complications have been reported, most of which have evolved favourably. The cases are widespread in Catalonia. No cases have been identified from other areas in Spain so far. Enterovirus A71 is a major cause of hand, foot and mouth disease and is particularly prevalent in parts of Southeast Asia, affecting thousands of children and infants each year.
Colistin resistance mechanism MCR-1
Plasmid-mediated colistin resistance mechanism MCR-1 in gram-negative bacteria The first detection of plasmid-mediated resistance to polymyxins (MCR-1) in China was reported in an article in Lancet Infectious Diseases on 18 November 2015.
On 26 May 2016, the Journal of Antimicrobial Agents and Chemotherapy published the first report of detection of the mcr-1 gene from a human sample in the United States. The mcr-1 and ESBL-carrying Escherichia coli isolate was cultured from the urine sample of a 49 year-old female patient who presented to a clinic in Pennsylvania with symptoms of a urinary tract infection.
Colistin is primarily used to treat multidrug-resistant Gram-negative infections, and development of colistin resistance will further severely limit treatment options, and even potentially result in untreatable infections. In the six months since its description in November 2015, the mcr-1 gene has already been detected in human, animal, food and environmental samples from multiple countries.
West Nile virus in Europe
As every year, ECDC monitors the West Nile virus transmission season (June to November) in EU Member States and neighbouring countries in order to inform blood safety authorities of affected areas and identify significant changes in the epidemiology of the disease.
This week ECDC started the seasonal monitoring of West Nile fever. As of 2 June, no human cases of West Nile fever have been reported in the EU and neighbouring countries.